Current treatments for acute spinal cord injury are based on animal models of human spinal
cord injury (SCI). These models have shown that the initial traumatic injury to cord tissue is …

Publisher Summary This chapter outlines the history and practice of animal spinal cord
contusion models, with particular emphasis on the Multicenter Animal Spinal Cord Injury …

Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal
regeneration and functional plasticity. It is well established that an upregulation of glial …

Spinal cord injury (SCI) produces profound alterations in lower urinary tract function.
Incontinence, elevated intravesical pressure, reflux, stones, and neurological obstruction …

Rodents, most commonly rats, mice, and guinea pigs are widely used to investigate urinary
storage and voiding functions, both in normal animals and in models of disease. An often …

Transplanting neuronal and glial restricted precursors (NRP/GRP) into a midthoracic injury 9
d after contusion improved bladder and motor function, diminished thermal hypersensitivity …

Behavioral outcome in rats with spinal cord injury (SCI) is the most important factor for
evaluating the extent of injury and treatment efficacy. For this purpose, a number of …

This report was produced by an Expert Working Group (EWG) consisting of UK-based
researchers, veterinarians and regulators of animal experiments with specialist knowledge …

Activation of endogenous neurogenesis by bioactive materials enables restoration of
sensory/motor function after complete spinal cord injury (SCI) via formation of new relay …

A detailed examination of the histopathological features of the clip compression injury in
mice was performed to understand the relationships between neurological function and …