Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …

Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …

Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

Stroke continues to be a serious and significant health problem in the USA and worldwide.
This article will emphasize the need for good laboratory practices, transparent scientific …

Neural stem cell (NSC) transplantation has been investigated as a means to reconstitute the
damaged brain after stroke. In this study, however, we investigated the effect on acute …

Intracerebral hemorrhage (ICH) is characterized by parenchymal hematoma formation with
surrounding inflammation. Matrix metalloproteinases (MMPs) have been implicated in the …

The significance of the hypoxia component of stroke injury is highlighted by hypermetabolic
brain tissue enriched with arachidonic acid (AA), a 22: 6n-3 polyunsaturated fatty acid. In an …

Intracerebral hemorrhagic transformation is a multifactorial phenomenon in which ischemic
brain tissue converts into a hemorrhagic lesion with blood-vessel leakage, extravasation …

Background and Purpose—This review discusses the state of our current knowledge on
hemorrhagic transformation (HT) and summarizes key factors to be considered when …

Background and Purpose—In animal models of acute ischemic stroke (AIS), the free radical–
trapping agent NXY-059 showed promise as a neuroprotectant. SAINT I and II were …