[HTML][HTML] Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology
D Basavarajappa, C Galindo-Romero, V Gupta… - Molecular Aspects of …, 2023 - Elsevier
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …
Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model
KS Yadav, AC Bisen, S Ishteyaque… - Journal of Ocular …, 2024 - liebertpub.com
Purpose: Glaucoma is a complex degenerative optic neuropathy characterized by loss of
retinal ganglion cells (RGCs) leading to irreversible vision loss and blindness. Solanum …
retinal ganglion cells (RGCs) leading to irreversible vision loss and blindness. Solanum …
[HTML][HTML] Posttranslational modifications of proteins in diseased retina
CR Starr, MS Gorbatyuk - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Posttranslational modifications (PTMs) are known to constitute a key step in protein
biosynthesis and in the regulation of protein functions. Recent breakthroughs in protein …
biosynthesis and in the regulation of protein functions. Recent breakthroughs in protein …
[HTML][HTML] Tau modulation through AAV9 therapy augments Akt/Erk survival signalling in glaucoma mitigating the retinal degenerative phenotype
KPM Thananthirige, N Chitranshi… - Acta neuropathologica …, 2024 - Springer
The microtubule-associated protein Tau is a key player in various neurodegenerative
conditions, including Alzheimer's disease (AD) and Tauopathies, where its …
conditions, including Alzheimer's disease (AD) and Tauopathies, where its …
Siponimod as a novel inhibitor of retinal angiogenesis: in vitro and in vivo evidence of therapeutic efficacy
Sphingosine-1-phosphate (S1P) receptors control endothelial cell proliferation, migration,
and survival. Evidence of the ability of S1P receptor modulators to influence multiple …
and survival. Evidence of the ability of S1P receptor modulators to influence multiple …
[HTML][HTML] Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension
C Zhang, N Yu, Q Qin, X Wu, Y Gu, T Liu… - … & Visual Science, 2023 - tvst.arvojournals.org
Purpose: Keratin 8/18 (KRT8/18), paired members of the intermediate filament family, have
shown vital functions in regulating physiological activities more than supporting the …
shown vital functions in regulating physiological activities more than supporting the …
[HTML][HTML] Efficacy of bioactive compounds of Chaihu (Radix Bupleuri Chinensis) on glaucomatous optic atrophy through interleukin-6/hypoxia inducible factor-1α signal …
Y Xirui, Z Hui, S Muhammad, D Feixue… - Journal of Traditional …, 2023 - ncbi.nlm.nih.gov
OBJECTIVE: To investigate the bioactive compounds of Chaihu (Radix Bupleuri
Chinensis)(RB) on glaucomatous optic atrophy (GOA), and to study the pharmacological …
Chinensis)(RB) on glaucomatous optic atrophy (GOA), and to study the pharmacological …
Research advancements in the immunomodulating effect of sphingosine-1-phosphate in skin diseases
M Ding, H Li, J Xu, K Ren, W Zhang - International Journal of … - journals.lww.com
Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that acts as an
extracellular and intracellular messenger in a variety of biological activities, many of which …
extracellular and intracellular messenger in a variety of biological activities, many of which …