[PDF][PDF] Exosomes as mediators of intercellular crosstalk in metabolism
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …
to the rapidly increased prevalence of overweight and obesity. To this point …
[HTML][HTML] Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …
Adiponectin, leptin and cardiovascular disorders
S Zhao, CM Kusminski, PE Scherer - Circulation research, 2021 - Am Heart Assoc
The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …
[HTML][HTML] Obesity and type 2 diabetes mellitus: Connections in epidemiology, pathogenesis, and treatments
R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
[PDF][PDF] Sphingolipids in metabolic disease: The good, the bad, and the unknown
The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …
recent addition to the lipids accumulated in obesity and have emerged as important …
[HTML][HTML] Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin
The contribution of cellular heterogeneity and architecture to white adipose tissue (WAT)
function is poorly understood. Herein, we combined spatially resolved transcriptional …
function is poorly understood. Herein, we combined spatially resolved transcriptional …
Properties and functions of adipose tissue macrophages in obesity
The expansion of adipose tissue (AT) in obesity is accompanied by the accumulation of
immune cells that contribute to a state of low‐grade, chronic inflammation and dysregulated …
immune cells that contribute to a state of low‐grade, chronic inflammation and dysregulated …
Insulin action and resistance in obesity and type 2 diabetes
MP Czech - Nature medicine, 2017 - nature.com
Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …
[HTML][HTML] Obesity-induced inflammation exacerbates clonal hematopoiesis
SK Pasupuleti, B Ramdas, SS Burns… - The Journal of …, 2023 - Am Soc Clin Investig
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …