Simple Summary Obesity is recognized as a chronic progressive disease and risk factor for
many human diseases. The high and increasing number of obese people may underlie the …

Objective Hyperleptinemia per se is sufficient to promote leptin resistance in the obese state.
Leptin sensitivity can be restored by reducing circulating leptin levels within a …

The liver gene expression of the peroxisomal β-oxidation enzyme acyl-coenzyme A oxidase
1 (ACOX1), which catabolizes very long chain fatty acids (VLCFA), increases in the context …

Obesity represents an abnormal fat accumulation resulting from energy imbalances. It
represents a disease with heavy consequences on population health and society economy …

Obesity and type 2 diabetes (T2D) have been found to be associated with abnormalities in
several organs, including the intestine. These conditions can lead to changes in gut …

Background. Obesity is a global health problem of epidemic proportions, which is
characterized by increased adipose tissue (AT) mass and significant repercussions in …

Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering
capacity in response to an overall positive energy balance. Over the course of expansion …

As a tumor suppressor and the most frequently mutated gene in cancer, p53 is among the
best-described molecules in medical research. As cancer is in most cases an age-related …

Background and Aims HCC is a leading cause of cancer‐related deaths globally with poor
outcome and limited therapeutic options. Although the myelocytomatosis (MYC) oncogene is …