Angiotensin II (Ang II), the biologically active component of renin-angiotensin system (RAS),
acts through two receptor subtypes, the AT1 and the AT2 receptor. All classic physiological …

It is becoming increasingly clear that signaling via G protein-coupled receptors is a diverse
phenomenon involving receptor interaction with a variety of signaling partners. Despite this …

The elevated level of tumour necrosis factor‐α (TNF‐α) in patients with heart failure has
triggered interest in investigating the role of TNF‐α in the pathogenesis of heart failure. Both …

Objectives: The purpose of this research was to evaluate the therapeutic value of initiating a
beta-blocker before an angiotensin-converting enzyme inhibitor (ACEI) in the treatment of …

Congestive heart failure (CHF) is a complex clinical syndrome characterized by exercise
intolerance, fatigability, dyspnea, and volume retention occurring as a consequence of …

Heart failure is the major cause of morbidity and mortality in the United States. Stage D heart
failure has a greater mortality rate than many cancers and has equivalent symptom burden …

BACKGROUND: In CIBIS III, initiating chronic heart failure (CHF) treatment with bisoprolol
(target dose 10 mg qd) followed by combination therapy with enalapril (target dose 10 mg …

Charlotte Pooler, RN, MN Anna Barkman, RN, MN cute myocardial infarction (AMI) and
myocardial contusion both result in injury to the heart. The underlying pathophysiology …

The expression of classic neurohormones, such as angiotensin II and noradrenaline, plays
an important role in disease progression in chronic heart failure (HF). This so-called …

Перепеч Никита Борисович-доктор медицинских наук, профессор, Научно-клинический
и образовательный центр «Кардиология» ФГБОУ ВО «Санкт-Петербургский …