The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices
remain ill-defined. Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-β …

Cells and the molecular processes underlying their behavior are highly dynamic.
Understanding these dynamic biological processes requires noninvasive continuous …

Symmetric and asymmetric activation of hematopoietic stem ce... : Current Opinion in
Hematology Symmetric and asymmetric activation of hematopoietic stem cells : Current …

Tumor cells display features that are not found in healthy cells. How they become immortal
and how their specific features can be exploited to combat tumorigenesis are key questions …

Changes in stem cell activity may underpin aging. However, these changes are not
completely understood. Here, we combined single-cell profiling with machine learning and …

Epigenetically regulated transcriptional plasticity has been proposed as a mechanism of
differentiation arrest and resistance to therapy. BCR-ABL leukemias result from leukemic …

Simple Summary Of all yearly deaths attributable to alcohol consumption globally,
approximately 12% are due to cancers, representing approximately 0.4 million deceased …

Hypofertility is a risk factor for the development of testicular germ cell tumors (TGCT), but the
initiating event linking these pathologies is unknown. We hypothesized that excessive …

During mammalian T cell development, the requirement for expansion of many individual T
cell clones, rather than merely expansion of the entire T cell population, suggests a possible …

Signaling proteins in HSC fate determination are unequally segregated during asymmetric cell
division | Journal of Cell Biology | Rockefeller University Press Skip to Main Content …