With detailed scientific background and up-to-date research, this book examines recent
developmental and cell biology, mechanobiology and stem cell biology discoveries to help …

B-Cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy in
children. Recently, we and others described a new subtype of the disease, affecting 60% of …

The discovery and implementation of immunomodulatory drugs (IMiD® s) has revolutionized
the treatment of many hematological malignancies due to the plethora of IMiD®-induced …

How hematopoietic stem cells (HSCs) coordinate their divisional axis relative to supportive
niche cells and whether or not their divisional orientation is important for stem cell-driven …

Hematopoietic stem cells (HSCs) are critical to the development of the hematopoietic system
during ontogeny and maintaining hematopoiesis under steady-state. Several genes …

The centrosome is a small non-membranous organelle composed of two centrioles and
surrounded by the pericentriolar material. The two primary functions of the centrosome are …

Hematopoietic stem cells (HSCs) take on the extraordinary role of sustaining life-long
production of blood cells. Despite their indisputable therapeutic potential, HSC biology is …

Asymmetric cell division (ACD) enables the maintenance of a stem cell population while
simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo …

The gene expression in eukaryotic cells is tightly regulated at various levels, including
transcription, RNA localization, RNA stability, translation, and post-translational modification …

Protein palmitoylation is a reversible lipid modification that regulates protein-membrane
interaction, activity, trafficking, and stability in a spatio-temporal manner similar to …