Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

Interleukins (IL)-4 and-13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …

Background The microbiota presents a compartmentalized distribution across different gut
segments. Hence, the exogenous microbiota from a particular gut segment might only …

Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease.
Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30 …

Currently, three classes of monoclonal antibodies targeting type 2 inflammation pathways
are available in Italy for the treatment of severe asthma: anti-IgE (Omalizumab), anti-IL-5/anti …

Interleukin (IL)-4 and-13 are structurally and functionally related cytokines sharing common
receptor subunits. They regulate immune responses and, moreover, are involved in the …

Background The objectives of this study were to delineate whether delirium in older adults is
associated with activation of the immune-inflammatory response system (IRS) as indicated …

Myeloid-lymphatic endothelial cell progenitors (M-LECP) are a subset of bone marrow (BM)-
derived cells characterized by expression of M2-type macrophage markers. We previously …

Viruses have evolved various mechanisms to evade host immunity and ensure efficient viral
replication and persistence. Several DNA tumor viruses modulate host DNA …

Dupilumab is a fully humanized monoclonal antibody, capable of inhibiting intracellular
signaling of both interleukin (IL)-4 and IL-13. These are two molecules that, together with …