Ligand recognition by αβ T cell receptors

MM Davis, JJ Boniface, Z Reich, D Lyons… - Annual review of …, 1998 - annualreviews.org
▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

Use of surface plasmon resonance to probe the equilibrium and dynamic aspects of interactions between biological macromolecules

P Schuck - Annual review of biophysics and biomolecular …, 1997 - annualreviews.org
▪ Abstract Surface plasmon resonance biosensors have become increasingly popular for the
qualitative and quantitative characterization of the specific binding of a mobile reactant to a …

T-cell-receptor affinity and thymocyte positive selection

SM Alam, PJ Travers, JL Wung, W Nasholds… - Nature, 1996 - nature.com
Abstract DEVELOPMENT of thymocytes involves two distinct outcomes resulting from
superficially similar events. Recognition by thymocytes of major histocompatibility complex …

Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors

DG Myszka - Current opinion in biotechnology, 1997 - Elsevier
Surface plasmon resonance based biosensors are being used to define the kinetics of a
wide variety of macromolecular interactions. As the popularity of this approach grows …

The structural basis of T cell activation by superantigens

H Li, A Llera, EL Malchiodi… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …

Crystal structure of a T-cell receptor β-chain complexed with a superantigen

BA Fields, EL Malchiodi, H Li, X Ysern, CV Stauffacher… - Nature, 1996 - nature.com
SUPERANTIGENS (SAgs) are viral or bacterial proteins that act as potent T-cell stimulants
and have been implicated in a number of human diseases, including toxic shock …

A Shannon entropy analysis of immunoglobulin and T cell receptor

JJ Stewart, CY Lee, S Ibrahim, P Watts… - Molecular …, 1997 - Elsevier
In 1970, before any antigen-bound immunoglobulin structure had been solved, Elvin Kabat
proposed that regions of high amino acid diversity would be the antigen binding sites of …

[HTML][HTML] Three-dimensional structure of the complex between a T cell receptor β chain and the superantigen staphylococcal enterotoxin B

H Li, A Llera, D Tsuchiya, L Leder, X Ysern… - Immunity, 1998 - cell.com
Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin
that activate T cells by binding to the Vβ domain of the T cell antigen receptor (TCR). The …

Paroxetine attenuates cardiac hypertrophy via blocking GRK2 and ADRB1 interaction in hypertension

X Sun, M Zhou, G Wen, Y Huang, J Wu… - Journal of the …, 2021 - Am Heart Assoc
Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations,
which have great implications in hypertension. GRK2 (G protein‐coupled receptor kinase 2) …

Global analysis of community‐associated methicillin‐resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection

C Burlak, CH Hammer, MA Robinson… - Cellular …, 2007 - Wiley Online Library
Community‐associated methicillin‐resistant Staphylococcus aureus (CA‐MRSA) is a threat
to human health worldwide. Although progress has been made, mechanisms of CA‐MRSA …