The current guideline represents the 6th edition of the “Japanese Clinical Practice Guideline
for Diabetes” which has been revised every three years since its first appearance in 2004 to …

Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …

Diabetic nephropathy (DN) is the second most frequent and prevalent complication of
diabetes mellitus (DM). The increase in the production of oxidative stress (OS) is induced by …

Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …

To evaluate the effect of multifactorial intervention on the onset and progression of diabetic
kidney disease in the patients with type 2 diabetes, we analyzed the effects of intensified …

Background Diabetic nephropathy (DN) is one of the most severe complications of diabetes
mellitus, which is characterized by early occurrence of albuminuria and end-stage …

Statins are widely used to prevent major cardiovascular events by lowering serum
cholesterol. There is evidence that statins have pleiotropic effects—that is, cholesterol …

For the purpose of predicting clinical outcomes in patients with diabetes and chronic kidney
disease, change in albuminuria is a good candidate to be a surrogate marker for future …

Statins are HMG-CoA reductase inhibitors with lipid-lowering effect and commonly used to
reduce cardiovascular risk in diabetic patients. The present study investigates the …

The diabetes epidemic and the increasing number of patients with diabetic chronic vascular
complications poses a significant challenge to health care providers. Diabetic kidney …