—Sir William Osler Acute aortic dissection (AD) is the most frequent and catastrophic
manifestation of the so-called acute aortic syndrome (which also includes intramural …

Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of
connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular …

Thoracic aortic diseases, including disease of the descending thoracic aorta (DTA), are
significant causes of death in the United States. Open repair of the DTA is a physiologically …

Background In international guidelines, risk estimation for thoracic ascending aortic
aneurysm (TAAA) is based on aortic diameter. We previously introduced the aortic size …

Between 43,000 and 47,000 people die annually in the United States from diseases of the
aorta and its branches and continues to increase. For the thoracic aorta, these diseases are …

BACKGROUND: We examined the genetic nature and phenotypic features of thoracic aortic
aneurysms (TAAs) and dissections in a large cohort of patients. METHODS: Interviews were …

Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

BACKGROUND: Rupture of an ascending thoracic aortic aneurysm (ATAA), which is
associated with significant mortality, occurs when the mechanical forces acting on the …

The aorta is a conduit that extends from the left ventricle that delivers pulsatile blood distally
to organs and tissue beds. Acute dissection of the ascending aorta is a lethal disease that …

Thoracic aortic aneurysms (TAAs) are potentially devastating, and due to their asymptomatic
behavior, pose a serious health risk characterized by the lack of medical treatment options …