Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery

C Koziol-White, E Gebski, G Cao, RA Panettieri Jr - Respiratory Research, 2024 - Springer
Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and
physiologically relevant ex vivo model for studying the intricacies of lung diseases, including …

Investigating the mechanisms underlying U46619-induced contraction on porcine lower esophageal sphincter

HP Kek, YT Su, KJ Lin, MC Yang, LC Chang… - … of Pharmacology and …, 2023 - ASPET
Gastroesophageal reflux disease (GERD) is associated with an incompetent lower
esophageal sphincter (LES), resulting in the reflux of gastric contents into the esophagus …

一种治疗慢性阻塞性气道疾病的新药: 那伐芬特罗

刘育如, 吴雯雯, 王刚 - 中国临床药理学与治疗学, 2024 - manu41.magtech.com.cn
那伐芬特罗(navafenterol) 是一单分子且同时具备毒蕈碱受体拮抗和β2 受体激动效应的新型
化合物, 正开发用于治疗慢性阻塞性肺疾病和哮喘等慢性阻塞气道疾病. 该药可显著改善肺功能 …

[HTML][HTML] Effect of Cholinergic Receptor Antagonists on the Potentiation of the Effect of Adenosine Receptor Blockers in People with Bronchial Asthma

L Mustafa, H Islami, M Havolli… - Biomedical and …, 2024 - biomedpharmajournal.org
Background: The interaction between adenosine receptor blockers and anticholinergic
substances in the treatment of bronchial asthma is an area of interest. The efficacy of such …

β-Adrenergic Receptor Antagonism of Cholinergic Stimulation of Airway Smooth Muscle Contraction: An Old Receptor Requires a Fresh Look

N Leblanc - Function, 2023 - academic.oup.com
The control of air flow resistance in the airways during breathing cycles is governed by a fine
balance between the parasympathetic and sympathetic branches of the autonomic nervous …

Advances in Drug Delivery Systems: A Mini-Review

LM Shaker, AA Al-Amiery… - Al-Ameed Journal for …, 2023 - ajmrhs.alameed.edu.iq
Drug delivery systems (DDS) refer to technologies designed to improve the safety and
efficacy of drugs by controlling their release, absorption, and distribution in the body. DDS …

Navafenterol, a new drug for the treatment of chronic obstructive airway disease

Y LIU, W WU, G WANG - Chinese Journal of Clinical …, 2024 - manu41.magtech.com.cn
Navafenterol is a new compound with both muscarinic receptor antagonist and β2 receptor
agonist effects in a single molecule, who is being developed for the treatment of chronic …

β-Adrenergic Receptor Antagonism of Cholinergic Stimulation of Airway Smooth Muscle Contraction: An Old Receptor Requires a Fresh Look

N Leblanc - europepmc.org
The control of air flow resistance in the airways during breathing cycles is governed by a fine
balance between the parasympathetic and sympathetic branches of the autonomic nervous …