Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel
disease (IBD) and other inflammatory conditions, but while their involvement is clear, their …

AIM To characterize the gut bacterial microbiota of patients with primary sclerosing
cholangitis (PSC) and ulcerative colitis (UC). METHODS Stool samples were collected and …

Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction;∼ 75% of patients have comorbid inflammatory bowel disease (IBD). We …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

Cholestatic liver disorders are caused by genetic defects, mechanical aberrations, toxins, or
dysregulations in the immune system that damage the bile ducts and cause accumulation of …

BACKGROUND & AIMS: A limited number of genetic risk factors have been reported in
primary sclerosing cholangitis (PSC). To discover further genetic susceptibility factors for …

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

T helper (Th) 17 cells are important for host defense against bacteria and fungi, but are also
involved in the pathogenesis of autoimmune diseases. In primary sclerosing cholangitis …

Approximately 60%‐80% of patients with primary sclerosing cholangitis (PSC) have
concurrent ulcerative colitis (UC). Previous genome‐wide association studies (GWAS) in …