Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Despite repeated associations between T cell infiltration and outcome, human ovarian
cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor …

The nature of the anti-tumor immune response changes as primary tumors progress and
metastasize. We investigated the role of resident memory (Trm) and circulating memory …

Gastric cancer (GC) represents the fifth most frequently diagnosed cancer worldwide, with a
poor prognosis in patients with advanced disease despite many improvements in systemic …

Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T
type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially …

Adoptive T cell therapies (ACTs) hold great promise in cancer treatment, but low overall
response rates in patients with solid tumors underscore remaining challenges in realizing …

While T-cell responses to cancer immunotherapy have been avidly studied, long-lived
memory has been poorly characterized. In a cohort of metastatic melanoma survivors with …

Background CD8+ tissue-resident memory T (T RM) cells, marked by CD103 (ITGAE)
expression, are thought to actively suppress cancer progression, leading to the hypothesis …

The success of checkpoint inhibitors in cancer treatment is associated with the infiltration of
tissue-resident memory T (Trm) cells. In this study, we found that about 30% of tumor …