How does adenosine control neuronal dysfunction and neurodegeneration?
RA Cunha - Journal of neurochemistry, 2016 - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …
G protein–coupled receptor oligomerization revisited: functional and pharmacological perspectives
Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
Health benefits of methylxanthines in cacao and chocolate
One may wonder why methylxanthines are so abundant in beverages used by humans for
centuries, or in cola-drinks that have been heavily consumed since their appearance. It is …
centuries, or in cola-drinks that have been heavily consumed since their appearance. It is …
[HTML][HTML] The endocannabinoid system as a target in cancer diseases: are we there yet?
The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …
decade. The immense data load published on its dual role in both tumorigenesis and …
[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum
Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …
dopaminergic neurotransmission. In the present essay we first review the extensive …
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
J Bonaventura, G Navarro… - Proceedings of the …, 2015 - National Acad Sciences
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key
modulators of striatal neuronal function. It has been suggested that the psychostimulant …
modulators of striatal neuronal function. It has been suggested that the psychostimulant …
Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease
MT Armentero, A Pinna, S Ferré, JL Lanciego… - Pharmacology & …, 2011 - Elsevier
Several selective antagonists for adenosine A2A receptors (A2AR) are currently under
evaluation in clinical trials (phases I to III) to treat Parkinson's disease, and they will probably …
evaluation in clinical trials (phases I to III) to treat Parkinson's disease, and they will probably …
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs
Background G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers
that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to …
that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to …
The GPCR heterotetramer: challenging classical pharmacology
S Ferré - Trends in pharmacological sciences, 2015 - cell.com
Two concepts are gaining increasing acceptance in G protein-coupled receptor (GPCR)
pharmacology:(i) pre-coupling of GPCRs with their preferred signaling molecules, and (ii) …
pharmacology:(i) pre-coupling of GPCRs with their preferred signaling molecules, and (ii) …
[HTML][HTML] G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)
G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …
signaling across the plasma membrane and a major class of drug targets. The canonical …