Genetics of eating disorders in the genome-wide era
Enabled by advances in high throughput genomic sequencing and an unprecedented level
of global data sharing, molecular genetic research is beginning to unlock the biological …
of global data sharing, molecular genetic research is beginning to unlock the biological …
Stem cell models for context-specific modeling in psychiatric disorders
Genome-wide association studies reveal the complex polygenic architecture underlying
psychiatric disorder risk, but there is an unmet need to validate causal variants, resolve their …
psychiatric disorder risk, but there is an unmet need to validate causal variants, resolve their …
[HTML][HTML] Food restriction and hyperactivity induce changes in corticolimbic brain dopamine and serotonin levels in female rats
Compelling data support altered dopamine (DA) and serotonin (5-HT) signaling in anorexia
nervosa (AN). However, their exact role in the etiopathogenesis of AN has yet to be …
nervosa (AN). However, their exact role in the etiopathogenesis of AN has yet to be …
[HTML][HTML] Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability
PIDD1 encodes p53-Induced Death Domain protein 1, which acts as a sensor surveilling
centrosome numbers and p53 activity in mammalian cells. Early results also suggest a role …
centrosome numbers and p53 activity in mammalian cells. Early results also suggest a role …
[HTML][HTML] From desire to dread—a neurocircuitry based model for food avoidance in anorexia nervosa
GKW Frank - Journal of clinical medicine, 2021 - mdpi.com
Anorexia nervosa is a severe psychiatric illness associated with food avoidance. Animal
models from Berridge et al. over the past decade showed that environmental ambience …
models from Berridge et al. over the past decade showed that environmental ambience …
[HTML][HTML] Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis
Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and
psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal …
psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal …
Hypothalamic subregion alterations in anorexia nervosa and obesity: Association with appetite‐regulating hormone levels
H Alzaid, JJ Simon, G Brugnara… - … Journal of Eating …, 2024 - Wiley Online Library
Objective Anorexia nervosa (AN) and obesity are weight‐related disorders with imbalances
in energy homeostasis that may be due to hormonal dysregulation. Given the importance of …
in energy homeostasis that may be due to hormonal dysregulation. Given the importance of …
Microgliosis: a double‐edged sword in the control of food intake
Maintaining energy balance is essential for survival and health. This physiological function
is controlled by the brain, which adapts food intake to energy needs. Indeed, the brain …
is controlled by the brain, which adapts food intake to energy needs. Indeed, the brain …
[HTML][HTML] Regulation of appetite-related neuropeptides by herbal medicines: research using microarray and network pharmacology
Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or
eliminated resulting in reducing or stopping food intake. Sipjeondaebo-tang (SDT) and …
eliminated resulting in reducing or stopping food intake. Sipjeondaebo-tang (SDT) and …
The Biology of Anorexia Nervosa: A New Narrative Overview
Anorexia nervosa, one of the most deadly mental disorders, is a pathophysiologically
complex mosaic of numerous extensively investigated pathways, and the current state of …
complex mosaic of numerous extensively investigated pathways, and the current state of …