Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Glia, a non-excitable cell type once considered merely as the connective tissue between
neurons, is nowadays acknowledged for its essential contribution to multiple physiological …

Abstract Changes in astrocyte channels, transporters, and metabolism play a critical role in
seizure generation and epilepsy. In particular, alterations in astrocyte potassium, glutamate …

In the past, water homeostasis of the brain was understood as a certain quantitative
equilibrium of water content between intravascular, interstitial, and intracellular spaces …

Traumatic brain injury (TBI) is a leading cause of death in young adults and a risk factor for
acquired epilepsy. Severe TBI, after a period of time, causes numerous neuropsychiatric and …

Traumatic brain injury (TBI) is a leading cause of acquired epilepsy referred to as post-
traumatic epilepsy (PTE), characterized by spontaneous recurrent seizures (SRS) that start …

Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms
underlying seizure activity have been intensely investigated. Alterations in astrocytic …