[PDF][PDF] Cardiac macrophages and emerging roles for their metabolism after myocardial infarction

EB Thorp - Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Interest in cardioimmunology has reached new heights as the experimental cardiology field
works to tap the unrealized potential of immunotherapy for clinical care. Within this space is …

Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

J Ritterhoff, R Tian - Nature Reviews Cardiology, 2023 - nature.com
Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

[HTML][HTML] Mitochondria as intracellular signalling organelles. An update

LD Popov - Cellular Signalling, 2023 - Elsevier
Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Selenium-Doped Mesoporous Bioactive Glass Regulates Macrophage Metabolism and Polarization by Scavenging ROS and Promotes Bone Regeneration In Vivo

D Chen, Z Liang, Z Su, J Huang, Y Pi… - … Applied Materials & …, 2023 - ACS Publications
Bone regeneration is complex and involves multiple cells and systems, with macrophage-
mediated immune regulation being critical for the development and regulation of …

Cardiac macrophage metabolism in health and disease

BJ Kopecky, KJ Lavine - Trends in Endocrinology & Metabolism, 2024 - cell.com
Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …

[HTML][HTML] Inflammation in myocardial ischemia/reperfusion injury: underlying mechanisms and therapeutic potential

J Francisco, DP Del Re - Antioxidants, 2023 - mdpi.com
Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

SIRT3 regulates clearance of apoptotic cardiomyocytes by deacetylating frataxin

J Gao, C Huang, L Kong, W Zhou, M Sun… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: Efferocytosis is an activity of macrophages that is pivotal for the resolution
of inflammation in hypertension. The precise mechanism by which macrophages coordinate …

[HTML][HTML] Resolvin D2 and its receptor GPR18 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target

M Zhao, Z Zheng, Z Yin, J Zhang, J Qin, J Wan… - Pharmacological …, 2023 - Elsevier
Accumulating evidence suggests that inflammation plays an important role in the
pathophysiology of the initiation and progression of cardiovascular and metabolic diseases …

[HTML][HTML] Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction

W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

X Long, M Liu, Y Nan, Q Chen, Z Xiao… - Advanced …, 2024 - Wiley Online Library
Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …