Burn trauma ranges from the minor burn to the devastating injury, which can impact on all
aspects of a person's life, including their aesthetic appearance, relationships with others …

Pruritus, the most common cutaneous symptom, is widely seen in many skin complaints. It is
an uncomfortable feeling on the skin and sometimes impairs patients' quality of life. At …

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for
minutes to hours. However, the neural basis for this effect is unclear, and the underlying …

Previous PET and fMRI brain imaging studies targeting neural networks processing itch
sensation have used histamine as the sole itch inducer. In contrast with histamine, cowhage …

Importance of the field: Pruritus is the predominant symptom of skin disease. Owing to the
poorly understood pathophysiology, the development of effective treatment modalities for …

Itch of peripheral origin requires information transfer from the spinal cord to the brain for
perception. Here, primate spinothalamic tract (STT) neurons from lumbar spinal cord were …

Chronic itch could be a presenting sign of malignancy. Pruritus of lymphoma is the common
prototype of paraneoplastic itch and can precede other clinical signs by weeks and months …

BACKGROUND: Epidermal nerve densities are increased in patients with atopic dermatitis
(AD), suggesting that it is partly responsible for the intense itching in the skin. Epidermal …

SIR, We report a potential contribution of semaphorin 3A (Sema3A) to the modulation of
epidermal innervation in atopic dermatitis (AD). Cutaneous nerve fibres are present at …

Background Physical symptoms of skin diseases have been shown to negatively affect
patients' wellbeing. Although insight into physical symptoms accompanying skin diseases is …