TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response

AT Billeter, N Galbraith, S Walker, C Lawson… - Surgery, 2015 - Elsevier
Introduction Hypothermia is a well-known risk factor for postoperative complications
because it prolongs the monocyte inflammatory response. The purpose of this study was to …

TRPV1 is involved in abdominal hyperalgesia in a mouse model of lipopolysaccharide-induced peritonitis and influences the immune response via peripheral …

Y Sugiyama, K Ishida, Y Yoshiyama, S Tanaka… - Life Sciences, 2023 - Elsevier
Aims The transient receptor potential vanilloid subfamily 1 (TRPV1) not only plays a role as
a nociceptor but also has some regulatory effects on the immune system. We investigated …

Deletion of transient receptor potential vanilloid type 1 receptors exaggerates renal damage in deoxycorticosterone acetate-salt hypertension

Y Wang, D Babánková, J Huang, GM Swain… - …, 2008 - Am Heart Assoc
To determine whether the transient receptor potential vanilloid type 1 (TRPV1) channel
provides protection against hypertension-induced renal damage, hypertension was induced …

[HTML][HTML] Cross-talk between neural and immune receptors provides a potential mechanism of homeostatic regulation in the gut mucosa

BM Assas, JA Miyan, JL Pennock - Mucosal immunology, 2014 - Elsevier
The relationship between elements of the immune system and the nervous system in the
presence of bacteria has been addressed recently. In particular, the sensory vanilloid …

[HTML][HTML] Genetic ablation of TRPV1 exacerbates pressure overload-induced cardiac hypertrophy

B Zhong, J Rubinstein, S Ma, DH Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Transient receptor potential vanilloid 1 (TRPV1) channels expressed in sensory nerves may
regulate vascular tone and cardiovascular function via their anti-inflammatory effects by …

Transient receptor potential vanilloid 1 agonists as candidates for anti-inflammatory and immunomodulatory agents

F Tsuji, M Murai, K Oki, I Seki, K Ueda, H Inoue… - European journal of …, 2010 - Elsevier
We recently demonstrated that SA13353 [1-[2-(1-adamantyl) ethyl]-1-pentyl-3-[3-(4-pyridyl)
propyl] urea], a novel transient receptor potential vanilloid 1 (TRPV1) agonist, inhibits TNF-α …

Effects of in-vitro modulation of TRPV1 activity on immune response of mice bearing metastatic breast carcinoma: Enhanced inflammatory response may hinder …

N Erin, M Akman - Life Sciences, 2021 - Elsevier
Aims Activation of transient receptor potential vanilloid 1 (TRPV1) ion channels inhibits
inflammation, enhance cytotoxic immune response, and may have therapeutic potential in …

Cold stress accentuates pressure overload-induced cardiac hypertrophy and contractile dysfunction: role of TRPV1/AMPK-mediated autophagy

S Lu, D Xu - Biochemical and biophysical research communications, 2013 - Elsevier
Severe cold exposure and pressure overload are both known to prompt oxidative stress and
pathological alterations in the heart although the interplay between the two remains elusive …

TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates

K Socała, M Jakubiec, M Abram, J Mlost… - Progress in …, 2024 - Elsevier
Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1),
also known as capsaicin receptor, in 1997 was a milestone achievement in the research on …

Senso-immunology: the past, present, and future

S Miyamoto, T Kondo… - The Journal of …, 2023 - academic.oup.com
Pain and mechanical stimulation are thought to be alarm systems that alert the brain to
physical abnormalities. When we experience unpleasant feelings in infected or traumatized …