Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

The conjugation of the 76 amino acid protein ubiquitin to other proteins can alter the
metabolic stability or non-proteolytic functions of the substrate. Once attached to a substrate …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Since the discovery of SUMO twenty years ago, SUMO conjugation has become a widely
recognized post-translational modification that targets a myriad of proteins in many …

The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates
the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

Glioblastoma (GBM) ranks among the most lethal of human cancers, containing glioma stem
cells (GSCs) that display therapeutic resistance. Here, we report that the lncRNA INHEG is …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Protein UFMylation, ie, post‐translational modification with ubiquitin‐fold modifier 1 (UFM1),
is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological …

Replication protein A (RPA) is a major regulator of eukaryotic DNA metabolism involved in
multiple essential cellular processes. Maintaining appropriate RPA dynamics is crucial for …