Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Protein post-translational modifications (PTMs) are important regulators of protein functions
and produce proteome complexity. SIRT1 has NAD+-dependent deacylation of acyl-lysine …

Background The exact mechanism of atrial fibrillation (AF)-induced heart failure (HF)
remains unclear. Proteomics and metabolomics were integrated to in this study, as to …

Background: Smoking is associated with carotid intima-media thickness (C-IMT). However,
knowledge about how genetics may influence this association is limited. We aimed to …

Background Enhanced late sodium current (INaL) is reportedly related to an increased risk
of atrial fibrillation (AF). Moricizine, as a widely used anti-arrhythmia drug for suppressing …

Myocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment
elevation MI (NSTEMI), is still a leading cause of death worldwide. Metabolomics technology …

Background Atrial fibrillation (AF) is the most common type of arrhythmia worldwide and is
associated with serious complications. This study investigated the metabolic biomarkers …

Rivaroxaban, an oral factor Xa inhibitor, has been used to treating a series of
thromboembolic disorders in clinical practice. Measurement of the anticoagulant effect of …

Atrial fibrillation involves an important type of heart arrhythmia caused by a lack of control in
the electrical signals that arrive in the heart, produce an irregular auricular contraction, and …

Cardiovascular diseases remain number 1 killer world-wide. New technologies, particularly
the novel approaches at genetics, transcriptomics, proteomics and metabolomics levels …