Objective To assess the efficacy of vaginal progesterone for the prevention of preterm birth
and neonatal morbidity and mortality in asymptomatic women with a twin gestation and a …

Progesterone has a broad spectrum of actions in the brain. Among these, the
neuroprotective effects are well documented. Progesterone neural effects are mediated by …

Therapeutic interventions can only be effective when administered during their specific
“therapeutic window.” A multitude of clinical trials based on highly successful preclinical …

Nucleotide oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome
may intimately contribute to sustaining damage after traumatic brain injury (TBI). This study …

Inhibitory extracellular matrices form around mature neurons as perineuronal nets
containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The …

Stroke is the second leading cause of death worldwide, and differences between men and
women have been documented in incidence, prevalence, and outcome. Here, we reviewed …

Oral contraceptives (OCs) are widely used yet understudied given their potential for public
health consequences. Emerging investigations scaling from single-subject, dense-sampling …

Ischemic stroke is the most common cerebrovascular disease and considered as a
worldwide leading cause of death. After cerebral ischemia, different pathophysiological …

Differences in the development of the male and female brain are an evolving area of
investigation. We are beginning to understand the underpinnings of male and female …

Hormone therapy, primarily progesterone and progestins, for central nervous system (CNS)
disorders represents an emerging field of regenerative medicine. Following a failed clinical …