[HTML][HTML] Recent advances in small molecules for improving mitochondrial disorders

L Meng, G Wu - RSC advances, 2023 - pubs.rsc.org
Mitochondrial disorders are observed in various human diseases, including rare genetic
disorders and complex acquired pathologies. Recent advances in molecular biological …

[HTML][HTML] In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease

J Pépin, L Francelle, MA Carrillo-de Sauvage… - Neuroimage, 2016 - Elsevier
Huntington's disease (HD) is an inherited neurodegenerative disease characterized by
motor, cognitive and psychiatric symptoms. Atrophy of the striatum has been proposed for …

Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats

ET Menze, MG Tadros, AM Abdel-Tawab, AE Khalifa - Neurotoxicology, 2012 - Elsevier
Huntington's disease (HD) is a progressive neurodegenerative disorder with a spectrum of
cognitive, behavioral, and motor abnormalities. The mitochondrial toxin 3-nitropropionic acid …

Neuroprotective effects of phytocannabinoid‐based medicines in experimental models of Huntington's disease

O Sagredo, MR Pazos, V Satta… - Journal of …, 2011 - Wiley Online Library
We studied whether combinations of botanical extracts enriched in either Δ9‐
tetrahydrocannabinol (Δ9‐THC) or cannabidiol (CBD), which are the main constituents of …

Taurine and its neuroprotective role

N Kumari, H Prentice, JY Wu - Taurine 8: Volume 1: The Nervous System …, 2013 - Springer
Taurine plays multiple roles in the CNS including acting as a neuro-modulator, an
osmoregulator, a regulator of cytoplasmic calcium levels, a trophic factor in development …

A pioneer study on human 3‐nitropropionic acid intoxication: Contributions from metabolomics

H Bendiksen Skogvold, M Yazdani… - Journal of Applied …, 2022 - Wiley Online Library
Abstract The neurotoxin 3‐nitropropionic acid (3‐NPA) is an inhibitor of succinate
dehydrogenase, an enzyme participating both in the citric acid cycle and the mitochondrial …

[PDF][PDF] Taurine, energy drinks, and neuroendocrine effects

JJ Caine, TD Geracioti - Cleve Clin J Med, 2016 - cdn.mdedge.com
Taurine is an amino acid found abundantly in brain, retina, heart, and reproductive organ
cells, as well as in meat and seafood. But it is also a major ingredient in popular “energy …

Pharmacodynamic and urinary metabolomics studies on the mechanism of Schisandra polysaccharide in the treatment of Alzheimer's disease

Y Liu, Z Liu, M Wei, M Hu, K Yue, R Bi, S Zhai, Z Pi… - Food & function, 2019 - pubs.rsc.org
Schisandra chinensis (Turcz.) Baill is produced mainly in northeast China, Korea and Japan.
Its fruit has been used in food as a nutritional and functional ingredient for centuries …

[HTML][HTML] Genistein improves 3-NPA-induced memory impairment in ovariectomized rats: impact of its antioxidant, anti-inflammatory and acetylcholinesterase …

ET Menze, A Esmat, MG Tadros, AB Abdel-Naim… - PLoS …, 2015 - journals.plos.org
Huntington's disease (HD) is a progressive neurodegenerative disorder. The pre-motor
symptomatic stages of the disease are commonly characterized by cognitive problems …

Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway

Y Li, Z Hu, B Chen, Q Bu, W Lu, Y Deng, R Zhu, X Shao… - Toxicology letters, 2012 - Elsevier
Methamphetamine (METH), a commonly abused psychostimulant, has been shown to
induce neuronal damage by causing reactive oxygen species (ROS) formation, apoptosis …