BACKGROUND: Recent studies suggest that the treatment of major depressive disorder
(MDD) with newer antidepressant drugs that simultaneously enhance norepinephrine and …

OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

Background Although clinicians frequently add a second medication to an initial, ineffective
antidepressant drug, no randomized controlled trial has compared the efficacy of this …

Objective: Two antidepressant medication combinations were compared with selective
serotonin reuptake inhibitor monotherapy to determine whether either combination …

Nonresponse to one or more antidepressants is common and an important public health
problem. This study evaluated the efficacy and safety of adjunctive aripiprazole or placebo to …

Objective: The authors compared the effectiveness of cognitive therapy and
pharmacotherapy as second-step strategies for outpatients with major depressive disorder …

BACKGROUND: Two broad treatment options exist for switching antidepressants for
depressed patients who fail to respond to a selective serotonin reuptake inhibitor (SSRI) …

Major depression (MD) is one of the most prevalent psychiatric disorders and a leading
cause of loss in work productivity. A combination of genetic and environmental risk factors …

Abstract Treatment resistant depression is common, persistent, and results in substantial
functional and social impairment. This study describes the development and preliminary …

Background. There is increasing literature on the unsatisfactory degree of remission that
current therapeutic strategies yield in unipolar depression. The aims of this review were to …