OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

Major depressive disorder (MDD) is an illness of great morbidity that affects many people
across the world. The current goal for treatment of MDD is to achieve remission (ie, no …

To compare the efficacy and safety of augmenting paroxetine with risperidone, buspirone,
valproate, trazodone, or thyroid hormone in patients with treatment-resistant depression …

Objective: Few data are available concerning the utility of augmentation in late-life
depression treatment. The authors examined likelihood, speed, and predictors of recovery in …

Objective: Evaluate the efficacy of L-methylfolate in combination with SSRI or SNRI
compared to SSRI or SNRI monotherapy in a major depressive episode. Design: A …

We used in vitro neurogenesis-based human neural stem cell (hNSCs) assays and rodent in
vivo behavioral assays to identify potential novel antidepressants. A combination of …

Objective: To evaluate the efficacy and tolerability of adjunctive ziprasidone in subjects with
treatment-resistant major depressive disorder (DSM-IV criteria) without psychotic features …

Depression's link to serotonin dysregulation is well-known. The monoamine theory posits
that depression results from impaired serotonin activity, leading to the development of …

Painful physical symptoms (PPS) are common in patients with depression. Our objective
was to evaluate the presence of PPS in a sample of SSRI non-or partial-responders with …

Objective: To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus
olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant …