Objective: To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus
olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant …

Objective: To test the hypothesis that in patients with major depressive disorder (MDD), the
response for specific Hamilton Depression Rating Scale items will differ for duloxetine …

Lithium is a unique and effective psychotropic agent with a long-standing history of clinical
use yet it is increasingly overlooked in lieu of newer agents. The purpose of the present …

The complex relationship between the use of antidepressants and suicidal behaviour is one
of the hottest topics of our contemporary psychiatry. Based on the literature, this paper …

Background Optimal successive treatment decisions are not well established after an initial
medication nonresponse in major depressive disorder or bipolar disorder. While practice …

The present study was aimed at evaluating the rapidity and duration of melatonin as an
antidepressant in a rat model of depression. The rats were subjected to a six-week period of …

Objective: To evaluate the efficacy of adjunctive aripiprazole to standard antidepressant
therapy (ADT) for patients with DSM-IV major depressive disorder with anxious/atypical …

Background: Effective management of major depressive disorder often includes the long-
term use of multiple medications, and the longer-term utility and safety of adjunctive …

Abstract Background Randomized controlled trials (RCTs) of vitamin D (VitD)
supplementation for depression have yielded inconsistent results. We conducted the first …

Adult hippocampal neurogenesis is affected in some neuropsychiatric disorders such as
depression. Numerous evidence indicates that plasma levels of melatonin are decreased in …