INTRODUCTION: For patients who continue to experience depressive symptoms despite an
adequate antidepressant SSRI trial, across-class switch is considered one of the best …

Objective: Depressive disorders cause substantial work impairment that can lead to
disability compensation. The authors compared treatment received for depression preceding …

Objective: To evaluate the safety and tolerability of aripiprazole adjunctive to standard
antidepressant therapy (ADT) for patients with major depressive disorder (DSM-IV-TR …

Introducción: Lograr la recuperación funcional lo más rápido posible en el tratamiento de la
depresión unipolar es un reto que la práctica clínica debe tratar de afrontar en la actualidad …

Approximately eight out of ten people experiencing a major depressive episode will have
one or more further episodes during their lifetime: a recurrent major depressive disorder …

Background Biological rhythm plays an important role in major depressive disorder (MDD).
The efficacy of antidepressant in biological rhythm remains unclear. This study is designed …

Background Most patients with major depressive disorder (MDD) report clinically significant
sleep problems. Pre-treatment insomnia has been associated with poorer treatment …

This treatment guideline draws on several international guidelines:(i) Practice Guidelines of
the American Psychiatric Association (APA) for the Treatment of Patients with Major …

BACKGROUND: Antidepressant monotherapy is effective in achieving treatment remission
in only approximately one third of patients with depression, and even switching to a second …

The goal of treatment of depression is full remission, but only a minority of patients will
achieve full remission with antidepressant monotherapy. Several forms of augmentation …