Background: Although complete nonresponse in depression treatment is considered to be a
major problem in clinical practice, research in this area is very limited. The objective of this …

Failure to achieve an adequate response after initial antidepressant treatment in patients
with depression is common and remains a clinical challenge. In recent years, some atypical …

Background This study evaluated the effect of sertraline with desvenlafaxine and sertraline
with mirtazapine on HAM-D score and inflammatory markers (IL-6 and TNF-α levels) in …

OBJECTIVE: We performed meta-analyses to obtain pooled estimates from controlled
clinical trials on the efficacy of aripiprazole in major depression disorder and manic phase of …

This randomized, double-blind, placebo-controlled trial evaluated the efficacy of CP-
601,927, an α4β2 nicotinic acetylcholine receptor partial agonist and an augmenting agent …

Background: Double-blind placebo-controlled trials are intended to control for the impact of
expectancy on outcomes. Whether they always achieve this is, however, questionable …

The bright light study investigated the use of bright white light to augment antidepressant
drug therapy in patients with a major depressive episode. Light is ubiquitous and linked to …

Zusammenfassung Das Spektrum unipolarer depressiver Erkrankungen macht den
Hauptteil affektiver Störungen aus und gehört mit einer Inzidenz von ca. 8–20% zu den …

Anxious depression, defined as major depressive disorder (MDD) accompanied by high
levels of anxiety, seems to be both common and difficult to treat, with antidepressant …

In 2 identical multicenter, double-blind, placebo-controlled trials, an 8-week prospective
treatment phase to ensure inadequate response to standard antidepressants was followed …