Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …

Cluster of differentiation 44 (CD44), a multi-functional cell surface receptor, has several
variants and is ubiquitously expressed in various cells and tissues. CD44 is well known for …

Hepatitis C virus (HCV) is remarkable at disrupting human immunity to establish chronic
infection. Upregulation of inhibitory signaling pathways (such as T cell Ig and mucin domain …

Background: Clinical and experimental evidence suggests that hepatitis C virus (HCV)
infection shows peculiar characteristics that strongly support a role in the development of …

Activation of the Fas receptor has been recently linked to apoptotic cell death after spinal
cord injury (SCI). Although it is generally considered that Fas activation mediates apoptosis …

The impaired function of CD8+ T cells is characteristic of hepatitis C virus (HCV) persistent
infection. HCV core protein has been reported to inhibit CD8+ T cell responses. To …

Inflammation contributes to the pathogenesis of ischemic acute kidney injury (AKI), and T
cells mediate the early phase of ischemia-reperfusion injury (IRI). The Fas/Fas ligand (FasL) …

Hepatitis C virus (HCV) is a major cause of chronic liver disease, cirrhosis and
hepatocellular carcinoma (HCC). In man, the pathobiological changes associated with HCV …

Abstract Interleukin (IL)-18 is a proinflammatory cytokine produced by leukocytes and
parenchymal cells (eg, tubular epithelial cells (TECs), mesangial cells, and podocytes). IL …

Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …