DNA and RNA methylation dynamics have been linked to a variety of cellular processes
such as development, differentiation, and the maintenance of genome integrity. The correct …

There is an urgent need for exploring new actionable targets other than androgen receptor
to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has …

Tumour progression and therapy tolerance are highly regulated and complex processes
largely dependent on the plasticity of cancer cells and their capacity to respond to stress …

Abstract N6-Methyladenosine (m6A) is the most prevalent RNA modification in various types
of RNA, including circular RNAs (circRNAs). Mounting evidence has shown that circRNAs …

The development of taxane resistance remains a major challenge for castration resistant
prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient …

Simple Summary Epigenetics, which leads to specific differentiation events and determines
gene expression states, has been recognized as a developmental landscape. Epigenetic …

We report here the efficient synthesis of prenyl-containing i 6 A-RNA bearing the
representative ACGCUAAAAA sequence through phosphoramidite chemistry. To determine …

In dogs, mammary cancer is the most common tumor type, especially in unspayed females.
As in humans, this type of cancer has spontaneous development and is influenced by …

Background DNA methylation markers are considered robust diagnostic features in various
cancer types, as epigenetic marks are commonly altered during cancer progression …

Prostate cancer is the most common non-cutaneous cancer among American men. Multiple
mechanisms are involved in tumorigenesis and progression to metastases. While androgen …