The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes.
Current evidence suggests that 25–30% of ischaemic stroke survivors develop immediate or …

Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the
pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However …

The spectrum of mixed brain pathologies expands beyond accompanying vascular
pathology in brains with Alzheimer's disease-related pathology. Co-occurrence of …

Human studies are reviewed concerning whether “aging”-related mechanisms contribute to
Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic …

As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …

White matter changes occur endemically in routine magnetic resonance imaging (MRI)
scans of elderly persons. MRI appearance and histopathological correlates of white matter …

Objective: Most pathologic studies indicate that significant vascular changes are found in the
majority of elderly persons, either alone or in association with neurodegenerative processes …

Accumulating evidence implicates small vessel cerebrovascular disease, visualized as
white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging, in the …