Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Human solid tumors are invariably less well‐oxygenated than the normal tissues from which
they arose. This so‐called tumor hypoxia leads to resistance to radiotherapy and anticancer …

A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts
radiotherapy. As a result, there has been longstanding active research into novel methods of …

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited
therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation …

Hepatocellular carcinoma (HCC) is a heterogeneous inflammation-driven malignancy,
which, despite significant advances in management, continues to portend a poor prognosis …

The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF)
transcriptional complex. HIF activity is deregulated in many human cancers, especially those …

PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1
increases the effectiveness of radiation in killing tumor cells. However, although the …

Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely
studied for more than six decades. Here we review the importance of hypoxia to …

Hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and
radioresistance of hepatocellular carcinoma (HCC); suppresses differentiation and …

Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …