[HTML][HTML] Bioactive Components of Areca Nut: An Overview of Their Positive Impacts Targeting Different Organs

H Sun, W Yu, H Li, X Hu, X Wang - Nutrients, 2024 - mdpi.com
Areca catechu L. is a widely cultivated tropical crop in Southeast Asia, and its fruit, areca nut,
has been consumed as a traditional Chinese medicinal material for more than 10,000 years …

Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems

AF Wang, JM Tian, XJ Zhao, ZH Li… - Angewandte Chemie …, 2023 - Wiley Online Library
An asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered
cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine …

[HTML][HTML] Hyperforin elicits cytostatic/cytotoxic activity in human melanoma cell lines, inhibiting pro-survival NF-κB, STAT3, AP1 transcription factors and the expression …

A Cardile, V Zanrè, R Campagnari, F Asson… - International Journal of …, 2023 - mdpi.com
Hyperforin (HPF), the main component responsible for the antidepressant action of
Hypericum perforatum, displays additional beneficial properties including anti-inflammatory …

[HTML][HTML] Food safety during pregnancy: current consideration

B Acharya, B Chowdhury, G Pattnaik… - International Journal …, 2023 - ijpsnonline.com
Food safety is critical during pregnancy. Pregnancy hormone changes reduce immune
function, making pregnant women more vulnerable to food-borne illnesses. The unborn …

[HTML][HTML] Regiodivergent biosynthesis of bridged bicyclononanes

L Ernst, H Lyu, P Liu, C Paetz, HMB Sayed… - Nature …, 2024 - nature.com
Medicinal compounds from plants include bicyclo [3.3. 1] nonane derivatives, the majority of
which are polycyclic polyprenylated acylphloroglucinols (PPAPs). Prototype molecules are …

[HTML][HTML] Assessment and Comparison of Phytochemical Constituents and Biological Activities between Full Flowering and Late Flowering of Hypericum perforatum L.

D Piatti, R Marconi, G Caprioli, S Angeloni… - Applied Sciences, 2023 - mdpi.com
This study assessed the impact of full and late flowering stages on the polyphenols and
enzyme inhibitory properties of Hypericum perforatum from Poland. Recognizing the …

Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

H Hu, L Li, Z Shi, X Lan, Y Zhang… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Psoriasis is a chronic immune‐mediated inflammatory skin
disease and the TNF‐α is an important therapeutic target of this disease. In our continuous …

Hyperatins A–D, highly oxidized polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum L. with hypoglycemic potential in liver cells

Y Guo, Q Xu, B Tao, X Huang, Y Cao, W Sun, C Qi… - Phytochemistry, 2024 - Elsevier
Abstract Hyperatins A–D (1–4), four previously undescribed polycyclic polyprenylated
acylphloroglucinols, were isolated from Hypericum perforatum L.(St. John's wort) …

Hyperforin ameliorates neuroinflammation and white matter lesions by regulating microglial VEGFR2/SRC pathway in vascular cognitive impairment mice

X Gao, J Chen, G Yin, Y Liu, Z Gu, R Sun… - CNS Neuroscience …, 2024 - Wiley Online Library
Aim To explore the neuroprotective potential of hyperforin and elucidate its underlying
molecular mechanisms involved in its therapeutic effects against vascular cognitive …

Hyperforin improves matrix stiffness induced nucleus pulposus inflammatory degeneration by activating mitochondrial fission

S Tuo, GAO Qichang, MA Yiming, GU Jiaao… - International …, 2024 - Elsevier
Objective The continuously increasing extracellular matrix stiffness during intervertebral disc
degeneration promotes disease progression. In an attempt to obtain novel treatment …