Cognitive impairment in Alzheimer's disease FAD4T mouse model: Synaptic loss facilitated by activated microglia via C1qA

C Zhang, H Qi, D Jia, J Zhao, C Xu, J Liu, Y Cui… - Life Sciences, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder
characterized by cognitive dysfunction. The connection between neuroinflammation and …

[PDF][PDF] Dissecting the role of the ABI3 S209F variant in human microglia–A functional

MS Pasculli - Neuroscience, 2024 - helda.helsinki.fi
The S209F variant of the Abelson Interactor family member 3 (ABI3) gene has emerged as a
risk factor for late-onset Alzheimer's Disease (LOAD). The ABI3 protein is functionally related …

Cell-type specific inference from bulk RNA-sequencing data by integrating single cell reference profiles via EPIC-unmix

C Tang, Q Sun, X Zeng, X Yang, F Liu, J Zhao, Y Shen… - bioRxiv, 2024 - biorxiv.org
Cell type specific (CTS) analysis is essential to reveal biological insights obscured in bulk
tissue data. However, single-cell (sc) or single-nuclei (sn) resolution data are still cost …

The Role of ABI3 in Obesity and Metabolic Regulation

DC Smith - 2024 - scholarworks.iupui.edu
Abstract Abelson Interactor Protein 3 is an adaptor protein involved in cytoskeletal
remodeling. ABI3 is predominantly expressed within mononuclear phagocytotic immune …

Chemical Constitutes from Tuber Indicum with Immunosuppressive Activity Uncovered by Transcriptome Analysis

L Sining, XA Li, Q Zhang, YJ Hu, HR Lei… - Li-Shi and Deng, Yun … - papers.ssrn.com
Three previously undescribed compounds including a polyketide (1) and two lactams (2 and
3) were obtained from T. indicum. The structures of new findings were elucidated by …