[HTML][HTML] Designing a VAR2CSA-based vaccine to prevent placental malaria
M Fried, PE Duffy - Vaccine, 2015 - Elsevier
Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …
[HTML][HTML] Progress and insights toward an effective placental malaria vaccine
B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …
malaria is progressively acquired during childhood and adults are usually protected against …
[HTML][HTML] The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains
M Dahlbäck, LM Jørgensen, MA Nielsen… - Journal of Biological …, 2011 - ASBMB
Malaria during pregnancy is a major health problem for African women. The disease is
caused by Plasmodium falciparum malaria parasites, which accumulate in the placenta by …
caused by Plasmodium falciparum malaria parasites, which accumulate in the placenta by …
[HTML][HTML] Cytoadherence and severe malaria
GC Alister, KMF Mustaffa… - The Malaysian journal of …, 2012 - ncbi.nlm.nih.gov
Malaria is a disease that causes enormous human morbidity and mortality. One feature of
mature Plasmodium falciparum-infected erythrocytes leading to the development of severe …
mature Plasmodium falciparum-infected erythrocytes leading to the development of severe …
[HTML][HTML] Var2CSA minimal CSA binding region is located within the N-terminal region
A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
[HTML][HTML] Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1
Members of the Plasmodium falciparum Erythrocyte Membrane protein 1 (PfEMP1) family
expressed on the surface of malaria-infected erythrocytes mediate binding of the parasite to …
expressed on the surface of malaria-infected erythrocytes mediate binding of the parasite to …
[HTML][HTML] The influence of sub-unit composition and expression system on the functional antibody response in the development of a VAR2CSA based Plasmodium …
The disease caused by Plasmodium falciparum (Pf) involves different clinical manifestations
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …
that, cumulatively, kill hundreds of thousands every year. Placental malaria (PM) is one such …
[HTML][HTML] Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade
Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing
to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated …
to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated …
[HTML][HTML] Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum
Background Rosetting is a Plasmodium falciparum virulence factor implicated in the
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …
VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to Plasmodium falciparum Placental Malaria
JYA Doritchamou, R Herrera, JA Aebig… - The Journal of …, 2016 - academic.oup.com
Background. Placental malaria is caused by Plasmodium falciparum–infected erythrocytes
(IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory …
(IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory …