Nanotechnology has shown tremendous promise in target-specific delivery of drugs and
genes in the body. Although passive and active targeted-drug delivery has addressed a …

The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of
ovarian carcinomas. Two general strategies have been developed for the targeted delivery …

In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …

The receptor for folic acid constitutes a useful target for tumor-specific drug delivery,
primarily because:(1) it is upregulated in many human cancers, including malignancies of …

We describe evidence for a novel mechanism of monoclonal antibody (MAb)–directed
nanoparticle (immunoliposome) targeting to solid tumors in vivo. Long-circulating …

Folate targeted drug delivery has emerged as an alternative therapy for the treatment and
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …

This study examines a new method for the remote loading of doxorubicin into liposomes. It
was shown that doxorubicin can be loaded to a level of up to 98% into large unilamellar …

The folate receptor (FR) is a potentially useful biological target for the management of many
human cancers. This membrane protein binds extracellular folates with very high affinity …

Unlike conventional liposomes, sterically stabilized liposomes, with their smaller volume of
distribution and reduced clearance, preferentially convey encapsulated drugs into tumor …

The aim of this study was to optimize the cationic PEGylated niosome-containing anti-cancer
drugs and siRNA to enhance the therapeutic response. Therefore, various surfactant-based …