As a novel lactate-derived post-translational modification (PTM), lysine lactylation (Kla) is
involved in diverse biological processes, and participates in human tumorigenesis …

Circular RNAs (circRNAs) are a crucial yet relatively unexplored class of transcripts known
for their tissue‐and cell‐type‐specific expression patterns. Despite the advances in single …

Advances in next generation sequencing (NGS) technologies resulted in a broad array of
large-scale gene expression studies and an unprecedented volume of whole messenger …

Long-read RNA sequencing (RNA-seq) holds great potential for characterizing
transcriptome variation and full-length transcript isoforms, but the relatively high error rate of …

Alternative polyadenylation (APA) is a crucial step in post-transcriptional regulation.
Previous bioinformatic studies have mainly focused on the recognition of polyadenylation …

Existing methods for computational prediction of transcription factor (TF) binding sites
evaluate genomic regions with similarity to known TF sequence preferences. Most TF …

The major transcript variants of human protein‐coding genes are annotated to a certain
degree of accuracy combining manual curation, transcript data, and proteomics evidence …

Here we demonstrate how selection bias in studies of pre-mRNA splicing can inadvertently
lead to inaccurate biological conclusions which nevertheless appear statistically robust. We …

Alternative splicing is a major contributor to transcriptome and proteome diversity in health
and disease. A plethora of tools have been developed for studying alternative splicing in …

Gas chromatography-mass spectrometry (GC-MS) is one of the major platforms for analyzing
volatile compounds in complex samples. However, automatic and accurate extraction of …