Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

The manifestations of cancerous phenotypes necessitate alterations at different levels of
information-flow from genome to proteome. The molecular alterations at different information …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis
plays a major role in tumor necrosis. Although several key necroptosis regulators including …

PURPOSE Investigations of the molecular basis for the development, progression, and
treatment of cancer increasingly use complementary genomic assays to gather multiomic …

The goal of the National Cancer Institute's (NCI's) Genomic Data Commons (GDC) is to
provide the cancer research community with a data repository of uniformly processed …

Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major
cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing …

In 2020, we identified cancer-specific microbial signals in The Cancer Genome Atlas
(TCGA). Multiple peer-reviewed papers independently verified or extended our findings …

To increase cancer patient survival and wellbeing, diagnostic assays need to be able to
detect cases earlier, be applied more frequently, and preferably before symptoms develop …

Accurate identification and effective removal of unwanted variation is essential to derive
meaningful biological results from RNA sequencing (RNA-seq) data, especially when the …