When animals walk overground, mechanical stimuli activate various receptors located in
muscles, joints and skin. Afferents from these mechanoreceptors project to neuronal …

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron
populations that are critical to process sensory information. Neurons in these areas are …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin,
muscles, bones, and viscera to detect touch and temperature as well as to mediate …

The skin is a multilayered organ, equipped with appendages (that is, follicles and glands),
that is critical for regulating body temperature and the retention of bodily fluids, guarding …

The spinal dorsal horn is a major site for the induction and maintenance of mechanical
allodynia, but the circuitry that underlies this clinically important form of pain remains …

Chronic itch is a major symptom of many inflammatory skin diseases. This type of pruritus is
thought to be facilitated by cytokines that activate cutaneous nerve fibers; however, the …

Cutaneous somatosensory modalities play pivotal roles in generating a wide range of
sensorimotor behaviors, including protective and corrective reflexes that dynamically adapt …

Single-cell RNA-sequencing and in vivo functional imaging provide expansive but
disconnected views of neuronal diversity. Here, we developed a strategy for linking these …