Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous
system, especially in brain region essential for learning and cognition. In addition to …

The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Assigning behavioral roles to genetically defined neurons within the lateral hypothalamus
(LH) is an ongoing challenge. We demonstrate that a subpopulation of LH GABAergic …

While energy balance is critical to survival, many factors influence food intake beyond
caloric need or" hunger." Despite this, some neurons that drive feeding in mice are routinely …

The number of new psychoactive substances (NPS) on the illicit drug market increases fast,
posing a need to urgently understand their toxicity and behavioural effects. However, with …

Animal knockout studies suggest that trace amine-associated receptor (TAAR) 1 is involved
in behavioral effects of psychostimulants such as cocaine. Recently, several highly selective …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Pain remains a challenging clinical condition and spinal GABAA receptors are crucial
modulators of pain processing. α2/α3-subtype GABAA receptors mediate the analgesic …

MT-45 is a synthetic opioid that was developed in the 1970s as an analgesic compound.
However, in recent years MT-45 has been associated with multiple deaths in Europe and …

Abnormal serotonergic pathways are implicated in numerous neuropsychiatric disorders
including alcohol and drug dependence (abuse). The human 5‐hydroxytryptamine …