[HTML][HTML] Progress towards elimination goals for viral hepatitis

AL Cox, MH El-Sayed, JH Kao, JV Lazarus… - Nature reviews …, 2020 - nature.com
The global burden of viral hepatitis is substantial; in terms of mortality, hepatitis B virus and
hepatitis C virus infections are on a par with HIV, malaria and tuberculosis, among the top …

Fibrosis regression after eradication of hepatitis C virus: from bench to bedside

DC Rockey, SL Friedman - Gastroenterology, 2021 - Elsevier
Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

FE Mózes, JA Lee, EA Selvaraj, ANA Jayaswal… - Gut, 2022 - gut.bmj.com
Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic
fatty liver disease. The aims of this study were to evaluate the individual diagnostic …

[PDF][PDF] 中国人群肝癌筛查指南(2022, 北京)

赫捷, 陈万青, 沈洪兵, 李霓, 曲春枫, 石菊芳, 孙凤… - 中华肿瘤杂志, 2022 - dzrmyy.com
中国人群的肝癌存在生存率低, 死亡率高的情况, 如何有效降低肝癌相关负担仍是中国公共卫生
和慢性病防控领域亟待解决的重大问题, 而肝癌人群筛查策略优化是值得持续探索的重要抓手和 …

[HTML][HTML] Diagnosis and treatment of VOD/SOS after allogeneic hematopoietic stem cell transplantation

F Bonifazi, F Barbato, F Ravaioli, M Sessa… - Frontiers in …, 2020 - frontiersin.org
Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare
complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and …

Hepatic benefits of HCV cure

V Calvaruso, A Craxì - Journal of hepatology, 2020 - Elsevier
Summary Direct-acting antiviral (DAA)-induced HCV clearance conceivably leads to
improved outcomes at all stages of liver disease. However, available data suggest that the …

[PDF][PDF] Changes in hepatic venous pressure gradient predict hepatic decompensation in patients who achieved sustained virologic response to interferon‐free therapy

M Mandorfer, K Kozbial, P Schwabl, D Chromy… - …, 2020 - Wiley Online Library
Background and Aims Sustained virologic response (SVR) to interferon (IFN)‐free therapies
ameliorates portal hypertension (PH); however, it remains unclear whether a decrease in …

[HTML][HTML] The FALCON program: Two phase 2b randomized, double-blind, placebo-controlled studies to assess the efficacy and safety of pegbelfermin in the treatment …

MF Abdelmalek, ED Charles, AJ Sanyal… - Contemporary clinical …, 2021 - Elsevier
Background Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic
fatty liver disease (NAFLD); no approved therapies for NASH currently exist. Pegbelfermin …

[HTML][HTML] 2020 Taiwan consensus statement on the management of hepatitis C: part (I) general population

ML Yu, PJ Chen, CY Dai, TH Hu, CF Huang… - Journal of the Formosan …, 2020 - Elsevier
Hepatitis C virus (HCV) infection remains a major public health issue with high prevalence in
Taiwan. Recently, the advent of direct-acting antiviral (DAA) agents, with higher efficacy …

Implications of the conformationally flexible, macrocyclic structure of the first-generation, direct-acting anti-viral paritaprevir on its solid form complexity and …

AY Sheikh, A Mattei, R Miglani Bhardwaj… - Journal of the …, 2021 - ACS Publications
Direct-acting antiviral regimens have transformed therapeutic management of hepatitis C
across all prevalent genotypes. Most of the chemical matter in these regimens comprises …