Caspases are intracellular proteases that propagate programmed cell death, proliferation,
and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict …

Recent work on the initial switches that trigger cell death has revealed surprising inventions
of nature that ensure the ordered suicide of a cell that has been selected for demise …

Misregulated innate immune signaling and cell death form the basis of much human disease
pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently …

The aspartate-specific cysteine protease caspase-1 is activated by the inflammasomes and
is responsible for the proteolytic maturation of the cytokines IL-1β and IL-18 during infection …

Glioblastoma (GBM) is an astrocytic brain tumor characterized by an aggressive clinical
course and intense resistance to all therapeutic modalities. Here, we report the identification …

During apoptosis, hundreds of proteins are cleaved by caspases, most of them by the
executioner caspase-3. However, caspase-7, which shares the same substrate primary …

Caspase-8 is an apoptotic protease that is activated at the cytosolic face of the cell
membrane. Activation relies on adaptor-induced dimerization of monomeric caspase-8 and …

Ubiquitin-mediated inactivation of caspases has long been postulated to contribute to the
regulation of apoptosis. However, detailed mechanisms and functional consequences of …

Caspase regulation and activation have been extensively studied since the discovery of this
class of proteases almost two decades ago, yet surprisingly few tools are available that can …

Caspases are cysteine proteases that are key effectors in apoptotic cell death. Currently,
there is a lack of tools that can be used to monitor the regulation of specific caspases in the …