Sleep disturbance is a prevalent and disabling comorbidity in Parkinson's disease (PD). We
performed multi-night (n= 57) at-home intracranial recordings from electrocorticography and …

Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson's
disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This …

Sleep disturbances profoundly affect the quality of life in individuals with neurological
disorders. Closed-loop deep brain stimulation (DBS) holds promise for alleviating sleep …

The globus pallidus plays a pivotal role In the basal ganglia circuit. Parkinson's disease Is
characterized by degeneration of dopamine-producing cells in the substantia nigra, which …

Increasing evidence suggests slow-wave sleep (SWS) dysfunction in Parkinson's disease
(PD) is associated with faster disease progression, cognitive impairment, and excessive …

Brain rhythms can facilitate neural communication for the maintenance of brain function.
Beta rhythms (13-35 Hz) have been proposed to serve multiple domains of human ability …

Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective
therapy in ameliorating the motor symptoms of Parkinson's disease (PD). However …

Background Sleep disturbance is a prevalent and highly disabling comorbidity in individuals
with Parkinson's disease (PD) that leads to worsening of daytime symptoms, reduced quality …

Increasing evidence associates slow-wave sleep (SWS) dysfunction with
neurodegeneration. Using a within-subject design in the nonhuman primate model of …

Adaptive deep brain stimulation (aDBS) is a promising therapeutic approach for subjects
with Parkinson's disease (PD) using neural signals as feedback control to adjust the level of …