Pleiotropic actions of PGRMC proteins in cancer

JK Pru - Endocrinology, 2022 - academic.oup.com
Progesterone receptor membrane component (PGRMC) proteins play important roles in
tumor growth, progression, and chemoresistance, of which PGRMC1 is the best …

Quo vadis PGRMC? Grand-scale biology in human health and disease

MA Cahill - Frontiers in Bioscience-Landmark, 2022 - researchoutput.csu.edu.au
The title usage of Latin Quo vadis 'where are you going'extends the question Unde venisti
from where 'did you come?'posed in the accompanying paper and extends consideration of …

Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer

K Baby, S Maity, CH Mehta, UY Nayak, GG Shenoy… - Scientific Reports, 2023 - nature.com
Non-small cell lung carcinomas (NSCLC) are the predominant form of lung malignancy and
the reason for the highest number of cancer-related deaths. Widespread deregulation of Akt …

Targeting human progesterone receptor (PR), through pharmacophore-based screening and molecular simulation revealed potent inhibitors against breast cancer

M Shahab, P Ziyu, M Waqas, G Zheng… - Scientific Reports, 2024 - nature.com
Breast cancer, the prevailing malignant tumor among women, is linked to progesterone and
its receptor (PR) in both tumorigenesis and treatment responsiveness. Despite thorough …

Pleiotropy of Progesterone Receptor Membrane Component 1 in Modulation of Cytochrome P450 Activity

IS Barata, J Rueff, M Kranendonk, F Esteves - Journal of xenobiotics, 2024 - mdpi.com
Progesterone receptor membrane component 1 (PGRMC1) is one of few proteins that have
been recently described as direct modulators of the activity of human cytochrome P450 …

Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma

S Solairaja, S Venkatabalasubramanian - The Journal of Membrane …, 2024 - Springer
Abstract Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate
oncogene with a prominent involvement in the pathogenesis of diverse cancers (ovarian …

[HTML][HTML] Preclinical Targeting of the PGRMC1-CK2 Axis with Silmitasertib: A Potential Strategy for Lung Adenocarcinoma Therapy

S Solaipriya, M Anbalagan… - Drug Research, 2024 - thieme-connect.com
Progesterone receptor membrane component 1 (PGRMC1) is a pleiotropic protein over-
expressed in lung adenocarcinoma (LUAD). The precise molecular mechanisms underlying …

[HTML][HTML] Молекулярные механизмы полового диморфизма в канцерогенезе

ГА Белицкий, КИ Кирсанов, ЕА Лесовая… - Успехи …, 2023 - cyberleninka.ru
Заболеваемость злокачественными новообразованиями нерепродуктивных органов,
как карциномами, так и саркомами, и смертность от них у мужчин в 1, 5 раза выше, чем …

[引用][C] Muhammad Shahab, Peng Ziyu 2, 7, Muhammad Waqas 3, Guojun Zheng 1Ε

YAB Jardan, GF Wondmie, M Bouhrhia - Scientific Reports, 2024