Cancer biomarkers: Emerging trends and clinical implications for personalized treatment

A Passaro, M Al Bakir, EG Hamilton, M Diehn, F André… - Cell, 2024 - cell.com
The integration of cancer biomarkers into oncology has revolutionized cancer treatment,
yielding remarkable advancements in cancer therapeutics and the prognosis of cancer …

A novel NET-related gene signature for predicting DLBCL prognosis

H Shi, Y Pan, G Xiang, M Wang, Y Huang, L He… - Journal of Translational …, 2023 - Springer
Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy.
Neutrophil extracellular traps (NETs) are pathogen-trapping structures in the tumor …

FOXP3 (in) stability and cancer immunotherapy

K Mortezaee - Cytokine, 2024 - Elsevier
Dysregulation of regulatory T cells (Tregs) is described in the context of inflammatory and
autoimmune diseases, and cancer. Forkhead box P3 (FOXP3) is a transcription factor that its …

FSTL3 promotes tumor immune evasion and attenuates response to anti-PD1 therapy by stabilizing c-Myc in colorectal cancer

H Li, N Zheng, A Guo, W Tang, M Li, Y Cao, X Ma… - Cell Death & …, 2024 - nature.com
Programmed cell death 1 ligand 1 (PDL1)/programmed cell death 1 (PD1) blockade
immunotherapy provides a prospective strategy for the treatment of colorectal cancer (CRC) …

[HTML][HTML] RAB22A as a predictor of exosome secretion in the progression and relapse of multiple myeloma

B Fan, L Wang, J Wang - Aging (Albany NY), 2024 - ncbi.nlm.nih.gov
Background: Multiple myeloma (MM) is an incurable malignant plasma cell disease. We
explored the role of RAB22A in exosome secretion, epithelial-mesenchymal transition (EMT) …

5-Fluorouracil resistance-based immune-related gene signature for COAD prognosis

H Yan, Q Ou, Y Chang, J Liu, L Chen, D Guo, S Zhang - Heliyon, 2024 - cell.com
Background Drug resistance is the primary obstacle to advanced tumor therapy and the key
risk factor for tumor recurrence and death. 5-fluorouracil (5-FU) chemotherapy is the most …

Moving toward improved immune checkpoint immunotherapy for advanced prostate cancer

MA De Velasco, Y Kura, K Fujita… - International Journal of …, 2024 - Wiley Online Library
Human prostate cancer is a heterogenous malignancy that responds poorly to
immunotherapy targeting immune checkpoints. The immunosuppressive tumor …

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

A Sawant, F Shi, EC Lopes, Z Hu, S Abdelfattah, J Baul… - bioRxiv, 2024 - biorxiv.org
Mutations in polymerases Pold1 and Pole exonuclease domains in humans are associated
with increased cancer incidence, elevated tumor mutation burden (TMB) and response to …