G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …

Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented
within the human genome. This evidence strongly suggests that these genomic regions …

Guanine (G)-rich nucleic acids can fold into G-quadruplex (G4) structures under permissive
conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro …

Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but
compared to the protein targeting literature our understanding of chemical matter that binds …

Noncoding RNAs are functional transcripts that are not translated into proteins. They
represent the largest portion of the human transcriptome and have been shown to regulate …

There are over 700,000 putative G4-quadruplexes (G4Qs) in the human genome, found
largely in promoter regions, telomeres, and other regions of high regulation. Growing …

For over two decades, the prime objective of the chemical biology community studying G-
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …

The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …

Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …

G-quadruplex (G4) is a noncanonical nucleic acid secondary structure that has implications
for various physiological and pathological processes and is thus essential to exploring new …