Cerebellar reserve refers to the capacity of the cerebellum to compensate for tissue damage
or loss of function resulting from many different etiologies. When the inciting event produces …

Seminal work in the 1990's found alterations in the cerebellum of individuals with social
disorders including autism spectrum disorder and schizophrenia. In neurotypical …

Objective To describe a new spinocerebellar ataxia (SCA48) characterized by early
cerebellar cognitive-affective syndrome (CCAS) and late-onset SCA. Methods This is a …

Background Ataxia is a sign of different disorders involving any level of the nervous system
and consisting of impaired coordination of movement and balance. It is mainly caused by …

Apart from its role in motor coordination, the importance of the cerebellum in cognitive and
affective processes has been recognized in the past few decades. Spinocerebellar ataxias …

Objective As gene-based therapies may soon arise for patients with spinocerebellar ataxia
(SCA), there is a critical need to identify biomarkers of disease progression with effect sizes …

Recent advances in understanding dominant spinocerebellar ataxias from clinical and
genetic points of view - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Social cognition refers to interpretation of socially relevant signals to understand intentions,
mental and emotional states of others. These signals may be verbal, or transmitted through …

Abstract Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that
manifests in midlife and progressively worsens with age. SCA6 is rare, and many patients …

Expansion of CAG trinucleotide repeats in ATXN1 causes spinocerebellar ataxia type 1
(SCA1), a neurodegenerative disease that impairs coordination and cognition. While ATXN1 …