Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …

No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …

Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated
process that involves the sensing, binding, engulfment, and digestion of apoptotic cells …

Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …

Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce
blood glucose levels and suppress appetite. Here we report a significant elevation of the …

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight.
There is ongoing debate about the mechanisms that mediate metformin's effects on energy …

Exercise confers numerous salutary effects that extend beyond individual organ systems to
provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular …